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KMID : 1007520070160050807
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Food Science and Biotechnology
2007 Volume.16 No. 5 p.807 ~ p.811
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Effect of [6]-Gingerol, a Pungent Ingredient of Ginger, on Osteoblast Response to Extracellular Reducing Sugar
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Choi Eun-Mi
Kim Young-Ho
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Abstract
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Diabetes is marked by high glucose levels and is associated with decreased bone mass and increased fracture rates. To determine if [6]-gingerol could influence osteoblast dysfunction induced by 2-deoxy-D-ribose (dRib), osteoblastic MC3T3-E1 cells was treated with dRib and [6]-gingerol and markers of osteoblast function and oxidized protein were examined. [6]-Gingerol (10-7 M) significantly increased the growth of MC3T3-E1 cells in the presence of 30 mM dRib (p<0.05). [6]-Gingerol (10-7 M) caused a significant elevation of alkaline phosphatase (ALP) activity, collagen content, and osteocalcin secretion in the cells. We then examined the effect of [6]-gingerol on the production of osteoprotegerin and protein carbonyl in osteoblasts. Treatment with [6]-gingerol (10-9 and 10-7 M) increased osteoprotegerin secretion in osteoblastic cells. Moreover, [6]-gingerol (10-9 and 10-7 M) decreased protein carbonyl contents of osteoblastic MC3T3-E1 cells in the presence of 30 Mm dRib. Taken together, these results demonstrate that [6]-gingerol inhibits dRib-induced damage and may be useful in the treatment of diabetes related bone diseases.
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KEYWORD
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[6]-gingerol, osteoblast, 2-deoxy-D-ribose, MC3T3-E1 cell
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